Publication
2021 -- Present
1. Surasiang T, Chumkiew S, Martviset P, Chantree P, Jamklang M. Mosquito larvae distribution and natural Wol-bachia infection in campus areas of Nakhon Ratchasima, Thailand. Asian Pac J Trop Med 2022; 15(7): 314-321.
2. Surasiang T, Noree C. Effects of A6E Mutation on Protein Expression and Supramolecular Assembly of Yeast Asparagine Synthetase.Biology. 2021;10(4):294.
1. Mosquito larva distribution and natural Wolbachia infection in campus areas of Nakhon Ratchasima, Thailand
This study revealed mosquito larvae habitats and the prevalence of mosquito species in the campus areas of Nakhon Ratchasima province. In Thailand, there have been reports on Wolbachia infections in insects and mosquito adults but there is no report on Wolbachia infection in mosquito larvae. Our study is the first report on Wolbachia infection rate in mosquito larvae which has never been reported in Thailand.
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by Thunyarat Surasiang , Sirilak Chumkiew , Pongsakorn Martviset , Pathanin Chantree , Mantana Jamklang
2. Effects of A6E Mutation on Protein Expression and Supramolecular Assembly of Yeast Asparagine Synthetase
by Thunyarat Surasiang and Chalongrat Noree*
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​Certain mutations causing extremely low abundance of asparagine synthetase (the enzyme responsible for producing asparagine, one of the amino acids required for normal growth and development) have been identified in humans with neurological problems and small head and brain size. Currently, yeast is becoming more popular in modeling many human diseases. In this study, we incorporate a mutation, associated with human asparagine synthetase deficiency, into the yeast asparagine synthetase gene to demonstrate that this mutation can also show similar effects as those observed in humans, leading to very low abundance of yeast asparagine synthetase and slower yeast growth rate. This suggests that our yeast system can be alternatively used to initially screen for any drugs that can help rescue the protein levels of asparagine synthetase before applying them to further studies in mammals and humans. Furthermore, this mutation might specifically be introduced into the asparagine synthetase gene of the target cancer cells in order to suppress the overproduction of asparagine synthetase within these abnormal cells, therefore inhibiting the growth of cancer, which might be helpful for patients with blood cancer to prevent them developing any resistance to the conventional asparaginase treatment.
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